An extended HLA-D region haplotype associated with celiac disease.
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چکیده
منابع مشابه
An extended HLA-D region haplotype associated with celiac disease.
Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class II markers of the known HLA-linked diseases. This association is primarily with the class II serologic specificities HLA-DR3 and -DQw2. We previously described a restriction fragment length polymorphism (RFLP) characterized by the presence of a 4.0-kilobase Rsa I fragment derived from an HLA class II b...
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This study is the first to describe a molecular marker that distinguishes the celiac disease HLA-D region haplotype from a serologically identical haplotype in unaffected controls. Using a DQ beta chain cDNA probe and the restriction endonuclease Rsa I, we have detected a polymorphic 4.0 kb fragment which, in DQw2 individuals, is associated with a 40-fold increased relative risk of developing c...
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for the RIVUR Trial Investigators Since publication of their article, the authors report no further potential conflict of interest. 1. Hoberman A, Keren R. Antimicrobial prophylaxis for urinary tract infection in children. N Engl J Med 2009;361:1804-6. 2. Ingelfinger JR, Stapleton FB. Antibiotic prophylaxis for vesicoureteral reflux — answers, yet questions. N Engl J Med 2014;370:2440-1. 3. Nel...
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After in vitro mixed lymphocyte culture, cytotoxic lymphocytes develop which have specificity for components of the main histocompatibility complex (MHC) 1 of the stimulating lymphocyte population (1, 2). The effector cells were found to be directed mainly against class I histocompatibility antigens, that is, the H2-K and H2D antigens in the mouse (3), and the HLA-A or HLA-B antigens in man (4)...
متن کاملStructural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype.
Celiac disease is strongly associated with the HLA class II D-region serologic markers DR3 (DRw17) and DQw2. Moreover, by restriction fragment length polymorphism analysis, greater than 90% of DR3 (DRw17), DQw2 celiac disease patients have a polymorphic 4.0-kilobase Rsa I DP B gene DNA fragment. The present study sought to determine if there is a unique HLA class II D-region A or B gene structu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.1.222